Erratum: BRI1 is a critical component of a plasma-membrane receptor for plant steroids

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A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid.

The plant hormone abscisic acid (ABA) regulates many physiological and developmental processes in plants. The mechanism of ABA perception at the cell surface is not understood. Here, we report that a G protein-coupled receptor genetically and physically interacts with the G protein alpha subunit GPA1 to mediate all known ABA responses in Arabidopsis. Overexpressing this receptor results in an A...

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Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid".

Liu et al. (Reports, 23 March 2007, p. 1712) reported that the Arabidopsis thaliana gene GCR2 encodes a seven-transmembrane, G protein-coupled receptor for abscisic acid. We argue that GCR2 is not likely to be a transmembrane protein nor a G protein-coupled receptor. Instead, GCR2 is most likely a plant homolog of bacterial lanthionine synthetases.

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Response to Comment on “A G Protein–Coupled Receptor Is a Plasma Membrane Receptor for the Plant Hormone Abscisic Acid”

Based entirely on in silica modeling and bioinformatic prediction, Johnston et al. (1) suggest that Arabidopsis GCR2 is neither a transmembrane protein nor a G protein– coupled receptor (GPCR), but rather a plant homolog of bacterial lanthionine synthetase (LanC) proteins. We provide experimental evidence to support our proposal that GCR2 may be a new type of GPCR. We initially predicted that G...

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Endosomal signaling of plant steroid receptor kinase BRI1.

The LRR receptor serine/threonine kinases are a major eukaryotic receptor family, for which the central regulatory mechanism of endosomal trafficking remains largely unadressed. We show that the steroid receptor BRI1 localizes to both plasma membrane and early endosomal compartments, even when observed at low, endogenous expression levels, and that its localization and turnover are independent ...

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Arabidopsis leaf plasma membrane proteome using a gel free method: Focus on receptor–like kinases

The hydrophobic proteins of plant plasma membrane still remain largely unknown.  For example in the Arabidopsis genome, receptor-like kinases (RLKs) are plasma membrane proteins, functioning as the primary receptors in the signaling of stress conditions, hormones and the presence of pathogens form a diverse family of over 610 genes. A limited number of these proteins have appeard in pr...

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ژورنال

عنوان ژورنال: Nature

سال: 2001

ISSN: 0028-0836,1476-4687

DOI: 10.1038/35075629